On September 29, 2012, the century-long peaceful co-existence of the Muslim & Buddhist at Ramu in Cox’s Bazaar have been deteriorated within a half day because of false defamation of holy Qu’ran. After that, reporter, columnist, academician have expressed their concern about the destruction of the communal harmony in Bangladesh. But a few of them tried to analyze critically this and its future implication. This paper is divided into the following sections: the first section will make an attempt to trace the historical development of Islamism in Bangladesh from the colonial period to present day. Later it will focus on Ramu mayhem and a few reasons why this event is unique. Moreover, the third section will highlight three case studies. The final section will introduce the concluding remark with a recommendation to take policy immediately to stop the politics of Islamism in Bangladesh.