The world is currently afflicted with a lethal infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), called coronavirus disease 2019 (COVID-19). The virus was first detected in Wuhan, China, in December of 2019, and spread rapidly throughout the world before being declared a global pandemic by the World Health Organization (WHO) on March 11, 2020. Thus, the ongoing pandemic has severely harmed the world's most developed countries and is posing a significant threat to low-and middle-income countries. The ongoing COVID-19 outbreak is anticipated to have a noteworthy effect on the Sahel, the world's poorest region with the most vulnerable populations to various infectious diseases. This study involved a systematic literature review. The objective of this study is to examine the policy response to Covid-19 in the region. This study employed systematic literature review in search, selection and analysis of the relevant retrieved documents. Covid-19 has caused socioeconomic disruption and a rising number of deaths in the Sahel region.